Speaker Details

Speaker

JOSEPH GOLDSTEIN

University of Texas

Joseph L. Goldstein is currently Chairman of the Department of Molecular Genetics at the University of Texas Southwestern Medical Center at Dallas. In 1985, he was named Regental Professor of the University of Texas. He also holds the Paul J. Thomas Chair in Medicine and the Julie and Louis A. Beecherl Distinguished Chair in Biomedical Science.
Dr. Goldstein and his colleague, Michael S. Brown, discovered the low density lipoprotein (LDL) receptor and worked out how these receptors control cholesterol homeostasis. At the basic level, this work opened the field of receptor-mediated endocytosis, and at the clinical level it helped lay the conceptual groundwork for development of drugs called statins that lower blood LDL-cholesterol and prevent heart attacks. Drs. Goldstein and Brown shared many awards for this work, including the Lasker Award in Basic Medical Research (1985), Nobel Prize in Physiology or Medicine (1985), and National Medal of Science (1988).
In more recent work, Drs. Goldstein and Brown discovered the SREBP family of transcription factors and showed how these membrane-bound molecules control the synthesis of cholesterol and fatty acids through a newly described process of Regulated Intramembrane Proteolysis. For this work, Drs. Brown and Goldstein received the Albany Medical Center Prize in Medicine and Biomedical Research (2003) and the Rolf Luft Award (2016).
Dr. Goldstein is currently Chairman of the Albert Lasker Medical Research Award Jury and is a member of the Boards of Trustees of the Howard Hughes Medical Institute and The Rockefeller University (Life Trustee). He is also a member of the U.S. National Academy of Sciences and a Foreign Member of the Royal Society.

Symposium Faculty

Elçin Ünal

University of California, Berkeley

Ali Deniz Güler

University of Virginia

Yasemin Sancak

Harvard Medical School

Ömer Yılmaz

Massachusetts Institute of Technology

Joseph L. Goldstein

University of Texas Southwestern Medical Center at Dallas

Michael S. Brown

University of Texas, Southwestern Medical Center

Linda Partridge

University College London

Bruce Spiegelman

Harvard Medical School

Leslie Vosshall

The Rockefeller University

Jens C. Brüning

Max Planck Institute

Ronald M. Evans

Salk Institute

Michael Czech

University of Massachusetts Medical School

Jean Schaffer

Washington University

Gerald Shulman

Yale University

Brenda Schulman

St. Jude Children's Research Hospital

Vamsi Mootha

Massachusetts General Hosptial
Columbia University

Peter Walter

University of California, San Francisco