Speaker Details

Speaker

Michael S. Brown

University of Texas, Southwestern Medical Center

Michael S. Brown received an M.D. degree in 1966 from the University of Pennsylvania. He was an intern and resident at the Massachusetts General Hospital, and a post doctoral fellow with Earl Stadtman at the National Institutes of Health. He is currently Paul J. Thomas Professor of Molecular Genetics and Director of the Jonsson Center for Molecular Genetics at the University of Texas Southwestern Medical School in Dallas. Dr. Brown and his colleague, Dr. Joseph L. Goldstein, discovered the low density lipoprotein (LDL) receptor, which controls cholesterol in blood and in cells. They showed that mutations in this receptor cause Familial Hypercholesterolemia, a disorder that leads to premature heart attacks. Their work laid the groundwork for drugs called statins that block cholesterol synthesis, increase LDL receptors, lower blood cholesterol and prevent heart attacks. Statins are taken daily by more than 20 million people worldwide. Brown and Goldstein shared many awards for this work, including the U.S. National Medal of Science and the Nobel Prize for Medicine or Physiology. Dr. Brown served for 16 years on the Board of Directors of Pfizer, and he is currently a Director of Regeneron Pharmaceuticals.

Symposium Faculty

Elçin Ünal

University of California, Berkeley

Ali Deniz Güler

University of Virginia

Yasemin Sancak

Harvard Medical School

Ömer Yılmaz

Massachusetts Institute of Technology

Joseph L. Goldstein

University of Texas Southwestern Medical Center at Dallas

Michael S. Brown

University of Texas, Southwestern Medical Center

Linda Partridge

University College London

Bruce Spiegelman

Harvard Medical School

Leslie Vosshall

The Rockefeller University

Jens C. Brüning

Max Planck Institute

Ronald M. Evans

Salk Institute

Michael Czech

University of Massachusetts Medical School

Jean Schaffer

Washington University

Gerald Shulman

Yale University

Brenda Schulman

St. Jude Children's Research Hospital

Vamsi Mootha

Massachusetts General Hosptial
Columbia University

Peter Walter

University of California, San Francisco