David W. Wallace Professor of Immunobiology; Investigator,
Howard Hughes Medical Institute
Yale University, HHMI
Ruslan Medzhitov received his Ph.D. degree from Moscow University in 1993. He performed his postdoctoral studies at Yale University School of Medicine from 1994 to 1999 in the laboratory of Charles Janeway, Jr. He has been on the faculty of Yale University since 1999 and is currently a David Wallace Professor of Immunobiology and an Investigator of the Howard Hughes Medical Institute. His research interests include inflammation, metabolism, food allergy and host-microbe interactions. His awards include: The William B. Coley Award from the Cancer Research Institute, The Emil von Behring Award, The Blavatnik Award for Young Scientists, The AAI – BD Biosciences Investigator Award, Emil von Behring Award, Howard Taylor Ricketts Award, Lewis S. Rosenstiel Award, The Shaw Prize in Life Science and Medicine, Vilcek Foundation Prize in Life Sciences, Lurie Prize in Biomedical Sciences, Else Kröner Fresenius Stiftung Prize and the Charles W. Bohmfalk Teaching prize. He is a member of the National Academy of Sciences, USA, a member of the Institute of Medicine of the National Academy and a member of EMBO. He received A Doctor Honoris Causae at the University of Munich and the Utrecht University and Professor Honoris Causae from Moscow University.
Talk title: Inflammation and Metabolism
Inflammation is a protective response against infection, injury and any other threat to homeostasis. Inflammation operates at the cost to other physiological processes. Acute systemic inflammation rearranges fuel allocation to support defenses and chronic inflammation induces metabolic adaptations to the prolonged deviation from metabolic homeostasis. In addition, inflammatory response induces metabolic alterations that promote tissue protection from inflammatory damage. The focus of this talk will be on the diverse mechanisms that are orchestrated by inflammatory mediators that promote either protection of disease susceptibility.