Speaker Details

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Speaker

DAVID MANGELSDORF, PhD

University of Texas

Alfred G. Gilman Distinguished Chair in Pharmacology; Raymond and Ellen Willie

Distinguished Chair in Molecular Neuropharmacology, University of Texas

Southwestern Medical Center

Dr. David J. Mangelsdorf is the Alfred G. Gilman Professor and Chair of the Department of Pharmacology at the University of Texas Southwestern Medical Center in Dallas, an Investigator of the Howard Hughes Medical Institute and a member of the National Academy of Sciences. Dr. Mangelsdorf runs a joint laboratory with Dr. Steven Kliewer, and together their research team is focused on nuclear receptor regulation of metabolism. This work led to the discovery of two new signaling pathways mediated by the endocrine factors FGF19 and FGF21, which govern metabolism in response to nutrient stress. Their research has uncovered several therapeutic targets that are being developed to treat diverse diseases such as obesity, diabetes, fatty liver disease, cholestasis, and even nematode parasitism.

Symposium Faculty

Russell Foster

University of Oxford

Peng Li

Tsinghua University

Christopher Glass

University of California San Diego

Takashi Kadowaki

University of Tokyo

Roger D. Kornberg

Stanford University

Judith Klumperman

University Medical Center Utrecht

Jeffrey Friedman

Rockefeller University

Jennifer Lippincott-Schwartz

Howard Hughes Medical Institute

David Sabatini

Massachusetts Institute of Technology

Satchindananda Panda

Salk Institute for Biological Studies

Anu Suomalainen

University of Helsinki

Tobias Walther

Harvard Medical School

David Mangelsdorf

University of Texas Southwestern Medical Center

Nilay Yapıcı

Cornell University

Semir Beyaz

Cold Spring Harbor Laboratory

Gülçin Pekkurnaz

University of California San Diego

Betül Kaçar

University of Arizona